Physical Education
neda Aghaei Bahmanbeglou; mohammad sherafati moghadam; farhad daryanoosh; Saeedeh Shadmehri; Shiva Jahani Golbar
Volume 28, Issue 1 , January and February 2021, , Pages 49-55
Abstract
Introduction: The complex pathway of a rapamycin target in mammals (mTORC1) is one of the important pathways in protein synthesis in the heart, which in type 1diabetes can led to impairment and is a factor for hypertrophy. The aim of this study is to investigate the effect of high intensity interval ...
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Introduction: The complex pathway of a rapamycin target in mammals (mTORC1) is one of the important pathways in protein synthesis in the heart, which in type 1diabetes can led to impairment and is a factor for hypertrophy. The aim of this study is to investigate the effect of high intensity interval training (HIIT) on the mTORC1 pathway in heart muscle tissue of type 1 diabetic rats. Materials and Methods: In this experimental study, 16 SpragueDawley male rats (with mean weight of 300±20 gr) were selected and after induction of diabetes by STZ and nicotinamide were randomly assigned into two groups: diabetic training (8 head) and diabetic control (8 head). The experimental group performed 4 days a week the exercise training for 4 weeks, while the control group did not have any training program. Independent T-test was used to analyze the data. Results: There was a significant increase in the content of AKT1 (p < 0.027), mTOR (p < 0.003) and P70S6K1 (p < 0.024) proteins in the training group compared to control group, while significant change was not observed in the content of 4EBP1 (p < 0.75) in the training group compared to control group. Conclusion: HIIT for 4 weeks can activate the pathway AKT1/mTOR/P70S6K1 on the mTORC1 pathway. Therefore, HIIT by this pathway could lead to physiologic hypertrophy in the heart of type 1 diabetic subjects.
Physical Education
Maryam Shabani; Mohammad Sharafati Moghadam; Farhad Daryanoosh; Hamed Alizade Pahlavani
Volume 24, Issue 5 , September and October 2018, , Pages 305-310
Abstract
Background Objectives: Cardiac troponin as a marker of heart, play a vital role in the diagnosis of heart disease. The purpose of this study was to assess the effect of four weeks high intensity interval training (HIIT) and aerobic training on troponin T content in healthy male rats’ myocardial ...
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Background Objectives: Cardiac troponin as a marker of heart, play a vital role in the diagnosis of heart disease. The purpose of this study was to assess the effect of four weeks high intensity interval training (HIIT) and aerobic training on troponin T content in healthy male rats’ myocardial tissue.Materials & Methods: In this study, 36 Wistar rats 2 months with an average weight 180±20 were selected and randomly assigned divided into three groups, control (n=12), HIIT (n=12), and aerobic (n=12) groups; experimental group 5 days a week in accordance with their training program for 4 weeks to exercise. After 4 weeks, ANOVA test and Bonferroni post hoc test were used for analysis.Results: The results showed a no significant difference between the mean troponin T HIIT exercise and control groups. Troponin T is also a no significant difference between the Aerobic training and control groups.Conclusions: Based on the findings of troponin T in none of the groups had no significant change, It seems that exercise HIIT and Aerobic training with duration of 4 weeks do not damage the heart tissue.